ABSTRACT
Background: Chikungunya virus, an alphavirus belonging tothe Togaviridae family, caused large scale outbreaks in severalparts of southern, western and eastern India in 2006. Wereport Chikungunya outbreak in Jamshedpur region in 2011.Objective: To know the seroprevalence and seasonal trendsof Chikungunya infection among the patients of the diseasewho attended to MGM Medical College, Jamshedpur, A tertiarycare hospital during 2011 to 2014.Materials & Methods: Present retrospective observationalstudies were conducted in the Microbiology Department ofMahatma Gandhi Medical College, Jamshedpur from August2011 to December 2014.Result: Serum samples of 323 patients presenting with fever,arthralgia, rash etc. were tested for anti-Chikungunya IgMantibody using MAC ELISA. 148/324 (47.9%) samples werepositive for anti Chikungunya IgM antibody. More males wereaffected compared to females. The most common age groupaffected was 29-49 year. Characteristically, pediatrics agegroup was least affected. The number of cases increased withincreasing age group.Conclusion: Screening for Chikungunya infection in theendemic areas, especially in monsoon season would improvethe quality of arboviral surveillance and potentially aid in clinicalmanagement of the disease.
ABSTRACT
Background: Japanese Encephalitis is one of the mostimportant causes of viral encephalitis worldwide, with anestimated 50,000 cases and 15,000 deaths annually. Thepresent study was undertaken to investigate theSeroprevalence and Seasonal Trend of Japanese Encephalitisin Jamshedpur.Methods: It was a hospital-based retrospective studyconducted from August 2011 to December 2017. A total of 571consecutive non-repetitive patients, satisfying the clinical casedefinition of JE as per the WHO guidelines, were included inthe study. Cerebrospinal fluid (CSF) and serum samples weretested for JEV-specific IgM antibodies by the NIV JE IgMCapture ELISA Kit.Results: Out of which 166/571 (29.07%) were JE positivediagnosed by IgM Mac ELISA antibody kit. We have observedthat in a period of six years, the JE positivity rate hassignificantly reduced from 39.84% in 2011 to 7.29% in 2017.Conclusions: A declining trend of JE was seen in this study,however further research work needs to be done to lookfor non-JE causes of JE. Surveillance & effective vaccinationshould be carried out regularly for early detection of animpending outbreak and to initiate timely preventive and controlmeasures.
ABSTRACT
Background: Dengue fever and Dengue Haemorrhagic feveris an acute viral disease caused by Dengue virus. The infectionis transmitted by female mosquito- Aedes aegypti. The presentstudy was undertaken to investigate the trend of Dengue andthe seasonal effect associated with it. During late August 2010,outbreak of dengue symptomatic patients was admitted toMGM Medical college hospital Jamshedpur. ELISA for antidengue antibodies confirmed the case as Dengue.Objective: This retrospective study was done to analyze thecirculating dengue virus seroprevalence and seasonal trendamong the patients of the disease who attended to MGMMedical College, Jamshedpur, A tertiary care hospital during2010 to 2015.Methods: It was a hospital-based retrospective studyconducted from September 2010 to December 2015. A total of342 consecutive non-repetitive patients, satisfying the clinicalcase definition of Dengue as per the WHO guidelines, wereincluded in the study. Serum samples were tested for Denguespecific IgM antibodies by NIV Dengue IgM Capture ELISA Kit.Results: Of the 342 patients attended, 110(32.16%) caseswere positive for Dengue IgM antibodies. There was asignificant reduction in the Dengue positivity rate from 31% in2010 to no cases in 2015. The majority of cases occurredduring the monsoon and post-monsoon season.Conclusions: A declining trend of Dengue was seen in thisstudy, however further research work needs to be done to lookfor non-Dengue causes of Dengue fever. Surveillance shouldbe carried out regularly for early detection of an impendingoutbreak and to initiate timely preventive and controlmeasures.